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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 663-675 doi: 10.1007/s11705-017-1623-5
关键词: gene therapy RNAi therapeutics dendrimer nanovectors gene silencing
Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu
《医学前沿(英文)》 2011年 第5卷 第2期 页码 203-207 doi: 10.1007/s11684-011-0138-6
Developing macromolecular therapeutics: the future drug-of-choice
Huining HE, Victor C. YANG, Weibing DONG, Junbo GONG, Jingkang WANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 10-17 doi: 10.1007/s11705-009-0291-5
关键词: worldwide challenging effective macromolecular self-owned intellectual
Human monoclonal antibodies as candidate therapeutics against emerging viruses
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 462-470 doi: 10.1007/s11684-017-0596-6
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses in vitro and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.
关键词: human monoclonal antibodies emerging infectious diseases SARS-CoV MERS-CoV Ebola virus
基于RNA的生物防治——一种作物保护新模式 Review
Matthew Bramlett, Geert Plaetinck, Peter Maienfisch
《工程(英文)》 2020年 第6卷 第5期 页码 522-527 doi: 10.1016/j.eng.2019.09.008
关键词: 基于RNA的生物防治 RNA干扰(RNAi) 科罗拉多马铃薯甲虫(CPB) 玉米根虫(CRW) 大豆臭虫(SSB)
Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan
《医学前沿(英文)》 2021年 第15卷 第4期 页码 629-637 doi: 10.1007/s11684-020-0825-2
关键词: COVID-19 cardio-cerebrovascular disease traditional Chinese medicine clinical features clinical therapeutics
Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene
Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 287-291 doi: 10.1007/s11684-009-0050-5
关键词: cyclin-dependent kinase 4 RNA interference plasmid lentiviral vector
Precision medicine in acute lymphoblastic leukemia
Ching-Hon Pui
《医学前沿(英文)》 2020年 第14卷 第6期 页码 689-700 doi: 10.1007/s11684-020-0759-8
关键词: acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy CAR T-cell therapy
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 603-622 doi: 10.15302/J-FASE -2021397
The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.
Enhanced penetration strategies for transdermal delivery
Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu
《化学科学与工程前沿(英文)》 2020年 第14卷 第3期 页码 378-388 doi: 10.1007/s11705-019-1913-1
关键词: transdermal delivery stratum corneum enhanced penetration therapeutics
Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 66-72 doi: 10.15302/J-FASE-2018229
Porcine viral diarrhea is an acute and highly contagious enteric disease of pigs that causes huge economic losses worldwide. Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are the main pathogens responsible for piglet viral diarrhea. However, currently there is no specific drug available for the effective treatment of viral diarrhea. Therefore, it is necessary to seek an effective method to diminish PEDV and TGEV infection rates. RNA interference has been applied successfully to inhibit the virus replication. It provides a potential strategy for breeding resistant pigs. In this study, four promoters and four short hairpin RNA (shRNA) vectors with LoxP sites at each end of the selectable marker genes were constructed to target PEDV and TGEV. These vectors were then transfected into porcine fetal fibroblasts, G418 resistant transfectants were confirmed by PCR and transgenic SCNT porcine blastocysts were obtained. These results have paved the way for future production of marker-free transgenic resistant to PEDV and TEGV pigs by SCNT.
关键词: piglet diarrhea RNAi PEDV TGEV transgenic resistance breeding
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19
Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, Lanjuan Li
《医学前沿(英文)》 2020年 第14卷 第5期 页码 664-673 doi: 10.1007/s11684-020-0810-9
关键词: coronavirus disease 2019 (COVID-19) mesenchymal stem cell acute respiratory distress syndrome stem cell therapeutics
间充质干细胞治疗人感染H7N9禽流感病毒所致急性呼吸窘迫综合征的临床研究——为新冠病毒肺炎救治提供新策略 Article
陈佳佳, 胡晨霞, 陈利军, 汤灵玲, 朱一新, 徐小微, 陈露, 高海女, 鲁晓庆, 俞亮, 戴霞红, 项春生, 李兰娟
《工程(英文)》 2020年 第6卷 第10期 页码 1153-1161 doi: 10.1016/j.eng.2020.02.006
2013年,H7N9病毒在哺乳动物宿主之间迅速传播,并具有人与人之间传播的风险。患者表现为重症肺炎、急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)和呼吸衰竭。间充质干细胞(mesenchymal stem cell, MSC)移植在病毒性肺炎的治疗中有广阔的前景,并于2013年作为应急性治疗方法来治疗H7N9感染的ARDS。该研究在单中心开展,为开放式临床研究。根据自愿和知情同意的原则,17例H7N9感染的ARDS患者移植同种异体经血来源的MSC作为治疗组,44例H7N9感染的ARDS患者作为对照组。与对照组相比,MSC移植显著降低了ARDS病死率(MSC治疗组和对照组死亡率分别为17.6%和54.5%)。此外,在对4名MSC移植患者进行为期5年的随访中,未发现MSC移植产生有害影响。总体而言,该研究结果表明MSC移植显著提高了H7N9感染的ARDS的存活率,并为开展临床前和临床应用MSC治疗H7N9感染的ARDS的研究提供了理论基础。由于H7N9和2019新型冠状病毒性肺炎(coronavirus disease 2019, COVID-19)临床表现相似(如ARDS和呼吸衰竭),并继发多器官功能障碍,因此基于MSC的疗法可能为COVID-19所致的ARDS患者获益。
标题 作者 时间 类型 操作
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
期刊论文
Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues
Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu
期刊论文
Developing macromolecular therapeutics: the future drug-of-choice
Huining HE, Victor C. YANG, Weibing DONG, Junbo GONG, Jingkang WANG,
期刊论文
Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD
Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan
期刊论文
Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene
Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,
期刊论文
ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC REVIEW
期刊论文
Enhanced penetration strategies for transdermal delivery
Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu
期刊论文
Construction of multiple shRNA vectors targeting PEDV and TGEV and production of transgenic SCNT porcine embryos
Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG
期刊论文
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19
Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, Lanjuan Li
期刊论文